Objective: This study aimed to investigate the effect of 8 weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type 2 diabetes mellitus (T2DM). Materials and Methods: 40 elderly men T2DM aged between 65 to 70 years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of 1000 mg Mulberry leaf extract, 3 times a day, was used for 2 months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of 90 minutes. Results: The results showed that the amount of salusin-ß and interleukin-6 in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusin-a increased significantly in the training (P= 0.001), training + supplement (P= 0.001) and supplement (P= 0.01) groups. Also, the results of the covariance analysis showed that the amount of salusin-ß and interleukin 6 were lower (P= 0.001), and the level of salusin-a was higher significantly in the training (P= 0.001), training +supplement (P= 0.001), and supplement (P= 0.001) groups compared to the control groups. Conclusion: It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T2DM elderly.

Objective: This study aimed to investigate the effect of 8 weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type 2 diabetes mellitus (T2DM). Materials and Methods: 40 elderly men T2DM aged between 65 to 70 years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of 1000 mg Mulberry leaf extract, 3 times a day, was used for 2 months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of 90 minutes. Results: The results showed that the amount of salusin-ß and interleukin-6 in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusin-a increased significantly in the training (P= 0.001), training + supplement (P= 0.001) and supplement (P= 0.01) groups. Also, the results of the covariance analysis showed that the amount of salusin-ß and interleukin 6 were lower (P= 0.001), and the level of salusin-a was higher significantly in the training (P= 0.001), training +supplement (P= 0.001), and supplement (P= 0.001) groups compared to the control groups. Conclusion: It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T2DM elderly.

Objective: Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of insulin-producing beta cells of the pancreas. The objective of the present study was to describe the one year (2019-2020) incidence of T1DM in Hamadan west region of Iran. Materials and Methods: All 25 new patients with T1DM resident of Hamadan and its suburbs registered in Besat Hospital, Hamadan, Iran, from March 2019 to 2020 were prospectively reviewed. Information including age, sex, place of residence (urban or rural), season of diagnosis and season of birth were taken from parents through face-to-face interviews. Results: During 1 year survey, a total of 57 cases of newly diagnosed T1DM were identified in our center. Among these, 25 patients were residents of Hamadan city and suburbs. Based on this15 per 100 000 per year new cases T1DM occurred in the resident population of Hamadan areas, higher in boys than in girls (18 vs. 11 per 100 000).The mean age of diagnosis was 8.03 yr. The peak incidence was observed at the age group of 10-14 years. 92% were urban .Most cases were diagnosed in the autumn (44%). 52% had a history of neonatal jaundice and 16% had stressful life events in the family before the onset of diabetes. Conclusion: Our study showed a relatively high incidence of T1DM according category of the WHO, being greater in boys and in the age group of 10 to 14 years. The incidence is lower than in some Middle Eastern countries.

Objective: The aim of this study was to determine and correlate the serum chromium in Carotid intima - media thickness (CIMT) in type 2 Diabetes Mellitus (T2DM) subjects. Materials and Methods: The present case – control study included 40 healthy controls and 45 T2DM subjects that were selected through non-probability (purposive) sampling by prior inclusion and exclusion criteria. Serum chromium (Cr) was detected and measured on inductively coupled “Plasma Optical Emission Spectrophotometer” (ICP- OES)- Carotid artery was examined with a 7.5-MHz linear-array transducer (Siemens Acuson x300) sonography. Data was analyzed by Student’s t test and Chi square test in the SPSS 22.0 (USA). Linear regression model was used for predicting carotid intima media thickness. Level of confidence interval of statistical significance was 95% (P= 0.05). Results: Serum Cr in controls and cases was noted 0.873 (± 0.162) and 0.281 (± 0.240) µg/ml (P= 0.001). Serum Cr proved negative correlation with random blood sugar (r= -0.145, P= 0.185), HbA1c (r= -0.145, P= 0.0001) and CIMT (r= -0.730, P= 0.0001). Multiple regression analysis model showed significant association of serum Cr (r= -0.730, P< 0.0001) and HbA1c (r= 0.754, P< 0.0001) with the CIMT. Conclusion: The present study reported serum Cr was inversely correlated with the carotid intima - media thickness that is a marker of atherosclerosis. Cr supplements may be advised to diabetics in clinical management.

Objective: Today, the association of blood groups as genetic traits has been confirmed in many diseases. However, its association with gestational diabetes mellitus (GDM) has not been investigated. Therefore, in this study, we investigated the relationship between blood groups and GDM. Materials and Methods: In this analytical cross-sectional study, pregnant women referred to Baqaeipur Clinic and Yazd Diabetes Research Center in 2015-2018Based on the information related to the results of the one-hour OGTT test and the two-hour glucose levels recorded in the file were divided into two groups (GDM, non GDM). Then other information about the participants in the study, including demographic information, medical history, ABO and Rh blood groups, abortion, delivery, and number of pregnancies were extracted from the file and analyzed using SPSS version 23 software. Results: Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P< 0.001), weight (P< 0.001), number of pregnancies (P< 0.001), delivery (P< 0.001), previous diseases (P< 0.001), and Rh (P= 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed. Conclusion: Finally, we concluded that the frequency of the B+ blood group is higher in the GDM group, however, there is no statistically significant relationship between ABO blood groups and GDM.

Objective: Today, the association of blood groups as genetic traits has been confirmed in many diseases. However, its association with gestational diabetes mellitus (GDM) has not been investigated. Therefore, in this study, we investigated the relationship between blood groups and GDM. Materials and Methods: In this analytical cross-sectional study, pregnant women referred to Baqaeipur Clinic and Yazd Diabetes Research Center in 2015-2018Based on the information related to the results of the one-hour OGTT test and the two-hour glucose levels recorded in the file were divided into two groups (GDM, non GDM). Then other information about the participants in the study, including demographic information, medical history, ABO and Rh blood groups, abortion, delivery, and number of pregnancies were extracted from the file and analyzed using SPSS version 23 software. Results: Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P< 0.001), weight (P< 0.001), number of pregnancies (P< 0.001), delivery (P< 0.001), previous diseases (P< 0.001), and Rh (P= 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed. Conclusion: Finally, we concluded that the frequency of the B+ blood group is higher in the GDM group, however, there is no statistically significant relationship between ABO blood groups and GDM.

Objective: The epidemiological transition and the increase of chronic diseases resulted in the rise of endocrine, nutritional and metabolic (ENM) diseases as causes of death. This study aimed to explore the death rate caused by ENM in Iran 2006-18. Materials and Methods: Secondary data analysis was done. The demographic data on death were extracted (age, sex and cause of death) at the provincial level from the death records registered by civil registration. The conditions and trends of ENM death were analyzed from 2006 to 2018. The differences were analyzed in terms of age, sex, place of residence, and over time through indicators of death rate, sex ratio, and years of life lost (YLL). Results: Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P< 0.001), weight (P< 0.001), number of pregnancies (P< 0.001), delivery (P< 0.001), previous diseases (P< 0.001), and Rh (P= 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed. Conclusion: 6,906 people were died in Iran between 2006- 2018 due to ENM diseases. The death rate from this disease increased from 3.5 per 100,000 people in 2006 to 8.4 in 2018. More women died, especially in old age, with the peak of death being at the age of 50 and older. ENM death resulted in the loss of 67,041 years of life.

Objective: The epidemiological transition and the increase of chronic diseases resulted in the rise of endocrine, nutritional and metabolic (ENM) diseases as causes of death. This study aimed to explore the death rate caused by ENM in Iran 2006-18. Materials and Methods: Secondary data analysis was done. The demographic data on death were extracted (age, sex and cause of death) at the provincial level from the death records registered by civil registration. The conditions and trends of ENM death were analyzed from 2006 to 2018. The differences were analyzed in terms of age, sex, place of residence, and over time through indicators of death rate, sex ratio, and years of life lost (YLL). Results: Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P< 0.001), weight (P< 0.001), number of pregnancies (P< 0.001), delivery (P< 0.001), previous diseases (P< 0.001), and Rh (P= 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed. Conclusion: 6,906 people were died in Iran between 2006- 2018 due to ENM diseases. The death rate from this disease increased from 3.5 per 100,000 people in 2006 to 8.4 in 2018. More women died, especially in old age, with the peak of death being at the age of 50 and older. ENM death resulted in the loss of 67,041 years of life.

Objective: The epidemiological transition and the increase of chronic diseases resulted in the rise of endocrine, nutritional and metabolic (ENM) diseases as causes of death. This study aimed to explore the death rate caused by ENM in Iran 2006-18. Materials and Methods: Secondary data analysis was done. The demographic data on death were extracted (age, sex and cause of death) at the provincial level from the death records registered by civil registration. The conditions and trends of ENM death were analyzed from 2006 to 2018. The differences were analyzed in terms of age, sex, place of residence, and over time through indicators of death rate, sex ratio, and years of life lost (YLL). Results: Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P< 0.001), weight (P< 0.001), number of pregnancies (P< 0.001), delivery (P< 0.001), previous diseases (P< 0.001), and Rh (P= 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed. Conclusion: 6,906 people were died in Iran between 2006- 2018 due to ENM diseases. The death rate from this disease increased from 3.5 per 100,000 people in 2006 to 8.4 in 2018. More women died, especially in old age, with the peak of death being at the age of 50 and older. ENM death resulted in the loss of 67,041 years of life.

Objective: The aim of this study was to determine and correlate the serum chromium in Carotid intima - media thickness (CIMT) in type 2 Diabetes Mellitus (T2DM) subjects. Materials and Methods: The present case – control study included 40 healthy controls and 45 T2DM subjects that were selected through non-probability (purposive) sampling by prior inclusion and exclusion criteria. Serum chromium (Cr) was detected and measured on inductively coupled “Plasma Optical Emission Spectrophotometer” (ICP- OES)- Carotid artery was examined with a 7.5-MHz linear-array transducer (Siemens Acuson x300) sonography. Data was analyzed by Student’s t test and Chi square test in the SPSS 22.0 (USA). Linear regression model was used for predicting carotid intima media thickness. Level of confidence interval of statistical significance was 95% (P= 0.05). Results: Serum Cr in controls and cases was noted 0.873 (± 0.162) and 0.281 (± 0.240) µg/ml (P= 0.001). Serum Cr proved negative correlation with random blood sugar (r= -0.145, P= 0.185), HbA1c (r= -0.145, P= 0.0001) and CIMT (r= -0.730, P= 0.0001). Multiple regression analysis model showed significant association of serum Cr (r= -0.730, P< 0.0001) and HbA1c (r= 0.754, P< 0.0001) with the CIMT. Conclusion: The present study reported serum Cr was inversely correlated with the carotid intima - media thickness that is a marker of atherosclerosis. Cr supplements may be advised to diabetics in clinical management.

Objective: The aim of this study was to determine and correlate the serum chromium in Carotid intima - media thickness (CIMT) in type 2 Diabetes Mellitus (T2DM) subjects. Materials and Methods: The present case – control study included 40 healthy controls and 45 T2DM subjects that were selected through non-probability (purposive) sampling by prior inclusion and exclusion criteria. Serum chromium (Cr) was detected and measured on inductively coupled “Plasma Optical Emission Spectrophotometer” (ICP- OES)- Carotid artery was examined with a 7.5-MHz linear-array transducer (Siemens Acuson x300) sonography. Data was analyzed by Student’s t test and Chi square test in the SPSS 22.0 (USA). Linear regression model was used for predicting carotid intima media thickness. Level of confidence interval of statistical significance was 95% (P= 0.05). Results: Serum Cr in controls and cases was noted 0.873 (± 0.162) and 0.281 (± 0.240) µg/ml (P= 0.001). Serum Cr proved negative correlation with random blood sugar (r= -0.145, P= 0.185), HbA1c (r= -0.145, P= 0.0001) and CIMT (r= -0.730, P= 0.0001). Multiple regression analysis model showed significant association of serum Cr (r= -0.730, P< 0.0001) and HbA1c (r= 0.754, P< 0.0001) with the CIMT. Conclusion: The present study reported serum Cr was inversely correlated with the carotid intima - media thickness that is a marker of atherosclerosis. Cr supplements may be advised to diabetics in clinical management.

Objective: This study aimed to conduct a systematic review about diabetes mellitus and COVID-19 severity, management, and mortality. Materials and Methods: Thirteen studies were included in this review, comprising a total of 1155 COVID-19 patients with diabetes mellitus as a significant comorbidity. Data regarding patient demographics and the prevalence of comorbidities, including smoking, hypertension, cardiovascular disease, chronic kidney disease, and chronic liver disease, were collected. Results: Among COVID-19 patients with diabetes mellitus, the majority were male (57.1%) compared to females (42.9%). The prevalence of comorbidities in COVID-19 are varied, with smokers accounting for 1-12.6%, hypertension ranging from 8-41.6%, diabetes mellitus ranging from 7.4-70.8%, cardiovascular disease ranging from 1.6-23.0%, chronic kidney disease ranging from 0.7-2.9%, and chronic liver disease ranging from 0.5-4.6%. In comparison to COVID-19 patients without diabetes, a higher proportion of patients with diabetes mellitus were admitted to the intensive care unit (36.8%). Among COVID-19 patients with diabetes mellitus, the survival rate was significantly higher at 62.2% compared to a lower rate of 13.4% observed among non-survivors with diabetes mellitus. Conclusion: This systematic review emphasizes the significance of diabetes mellitus as a comorbidity in COVID-19 patients, increasing the risk of ICU admission. These findings emphasize the importance of identifying and effectively managing diabetes mellitus as a comorbidity in COVID-19 patients to enhance overall outcomes.

Objective: This study aimed to conduct a systematic review about diabetes mellitus and COVID-19 severity, management, and mortality. Materials and Methods: Thirteen studies were included in this review, comprising a total of 1155 COVID-19 patients with diabetes mellitus as a significant comorbidity. Data regarding patient demographics and the prevalence of comorbidities, including smoking, hypertension, cardiovascular disease, chronic kidney disease, and chronic liver disease, were collected. Results: Among COVID-19 patients with diabetes mellitus, the majority were male (57.1%) compared to females (42.9%). The prevalence of comorbidities in COVID-19 are varied, with smokers accounting for 1-12.6%, hypertension ranging from 8-41.6%, diabetes mellitus ranging from 7.4-70.8%, cardiovascular disease ranging from 1.6-23.0%, chronic kidney disease ranging from 0.7-2.9%, and chronic liver disease ranging from 0.5-4.6%. In comparison to COVID-19 patients without diabetes, a higher proportion of patients with diabetes mellitus were admitted to the intensive care unit (36.8%). Among COVID-19 patients with diabetes mellitus, the survival rate was significantly higher at 62.2% compared to a lower rate of 13.4% observed among non-survivors with diabetes mellitus. Conclusion: This systematic review emphasizes the significance of diabetes mellitus as a comorbidity in COVID-19 patients, increasing the risk of ICU admission. These findings emphasize the importance of identifying and effectively managing diabetes mellitus as a comorbidity in COVID-19 patients to enhance overall outcomes.

Objective: In the last two decades, genetic studies have strongly supported the effective role of genetic factors on the synthesis of insulin from the pancreas. The purpose of this research is to determine the effect of aerobic and resistance exercises on the expression of NeruoD1 and PDX1 in pancreatic tissue, as well as serum insulin and glucose levels in type 2 diabetic rats.

Objective: Determining diabetic foot risk levels and risk factors and treating foot problems is one of the main components of the prevention of diabetic foot ulcers (DFU). This study aimed to determine diabetic foot risk levels and risk factors in diabetic people.